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PAK
货号 | 产品名 | CAS号 | 信息 |
---|---|---|---|
CSN17173 | PF-3758309 | 898044-15-0 | PF-3758309 is an inhbitor of PAKs with IC50 of 1.3 nM for PAK4, which inhbits tumor growth in HCT116, A549, M24met and other xenograft tumor models. |
CSN17983 | (E)-3-(6-aminopyridin-3-yl)-N-((5-(4-(4,4-difluoropiperidine-1-carbonyl)phenyl)-7-(4-fluorophenyl)benzofuran-2-yl)methyl)acrylamide | 1643913-93-2 | PAK4-IN-1 is an inhibitor of p21-activated kinases (PAKs), with IC50 of ≤100 nM in MTT assay. |
CSN26728 | NVS-PAK1-C | 2250019-95-3 | NVS-PAK1-C is a potent, ATP-competitive and specific allosteric PAK1 inhibitor probe with IC50 values of 5 nM and 6 nM for dephosphorylated PAK1 and phosphorylated PAK1, respectively. NVS-PAK1-C is also against dephosphorylated PAK2 (IC50=270 nM) and phosphorylated PAK2 (IC50=720 nM)[1]. |
CSN20017 | NVS-PAK1-1 | 1783816-74-9 | NVS-PAK1-1 is a potent allosteric inhibitor of p21-activated kinase PAK1, a serine-threonine kinase that is upregulated in many cancers. NVS-PAK1-1 has an IC50 value of 5 nM for dephoshorylated PAK1 and 6 nM for phosphorylated PAK1 in an in vitro dephosphorylation assay. |
CSN25301 | LCH-7749944 | 796888-12-5 | LCH-7749944 is a novel and potent p21-activated kinase 4 (PAK4) inhibitor that suppresses proliferation and invasion in human gastric cancer cells through downregulation of PAK4/c-Src/EGFR/cyclin D1 pathway and causes successful inhibition of EGFR activity. |
CSN18267 | IPA-3 | 42521-82-4 | IPA-3 is a selective non-ATP competitive PAK1 inhibitor with IC50 of 2.5 μM, no inhibition to group II PAKs (PAKs 4-6). |
CSN17987 | G-5555 | 1648863-90-4 | G-5555 is a selective PAK1 inhibitor (Ki=3.7 nM). |
CSN15824 | FRAX597 | 1286739-19-2 | FRAX597, a small-molecule pyridopyrimidinone, is a potent and ATP competitive inhibitor of the group I PAKs (PAK1 IC50= 8 nM, PAK2 IC50= 13 nM, PAK3 IC50= 19 nM). |
CSN17596 | FRAX486 | 1232030-35-1 | FRAX486 is a selective inhibitor of group I PAKs with IC50s of 8.25/39.5, /55.3 nM for PAK1/PAK2/PAK3 respectivelt and less potent for PAK4 (IC50=779 nM). |
CSN17853 | FRAX1036 | 1432908-05-8 | FRAX-1036 is a potent and selective PAK1 inhibitor. |
CSN18571 | APTO-253 | 916151-99-0 | APTO-253 is a small molecule with potent anti-tumor activity in cancer cells via induction of the gene that expresses the Kruppel-like factor 4 (KLF4) master transcription factor, leading to cell cycle inhibition and programmed cell death. |